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ANSWER: Rebekah (Genesis 25:21, 24-26)
21 And Isaac prayed to the Lord for his wife, because she was barren. And the Lord granted his prayer, and Rebekah his wife conceived.
....24 When her days to give birth were completed, behold, there were twins in her womb. 25 The first came out red, all his body like a hairy cloak, so they called his name Esau. 26 Afterward his brother came out with his hand holding Esau's heel, so his name was called Jacob. Isaac was sixty years old when she bore them.